Erik Andersen Associate Professor

Research Summary: 

The Andersen laboratory uses quantitative and molecular genetics to understand the polymorphisms that underlie multigenic traits of medical, ecological, and evolutionary importance. In addition to genetics, we use new sequencing technologies, high-throughput phenotyping assays, and other genomic tools to determine the molecular mechanisms for how genetic variation causes phenotypic differences. We have broad research interests, including responses to microbial and chemical stresses, drug sensitivities, and aging-related processes.

Selected Publications:

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations.
Crombie TA, Zdraljevic S, Cook DE, Tanny RE, Brady SC, Wang Y, Evans KS, Hahnel S, Lee D, Rodriguez BC, Zhang G, van der Zwagg J, Kiontke K, Andersen EC. Elife. 2019 Dec 3;8. pii: e50465. doi: 10.7554/eLife.50465.

Selection and gene flow shape niche-associated variation in pheromone response.  Lee D, Zdraljevic S, Cook DE, Frézal L, Hsu JC, Sterken MG, Riksen JAG, Wang J, Kammenga JE, Braendle C, Félix MA, Schroeder FC, Andersen EC.  Nat Ecol Evol. 2019 Oct;3(10):1455-1463. doi: 10.1038/s41559-019-0982-3. Epub 2019 Sep 23.

Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism.
Zdraljevic S, Fox BW, Strand C, Panda O, Tenjo FJ, Brady SC, Crombie TA, Doench JG, Schroeder FC, Andersen EC.  Elife. 2019 Apr 8;8. pii: e40260. doi: 10.7554/eLife.40260.

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles.  Hahnel SR, Zdraljevic S, Rodriguez BC, Zhao Y, McGrath PT, Andersen EC.  PLoS Pathog. 2018 Oct 29;14(10):e1007226. doi: 10.1371/journal.ppat.1007226. eCollection 2018 Oct.

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.  Zdraljevic S, Strand C, Seidel HS, Cook DE, Doench JG, Andersen EC.  PLoS Genet. 2017 Jul 12;13(7):e1006891. doi: 10.1371/journal.pgen.1006891. eCollection 2017 Jul.

 

Selected Honors:

2014 - Pew Scholar in the Biomedical Sciences

2015 - Editorial Board Member of Trends in Genetics

2015 - March of Dimes Basil O’Connor Research Scholar

2015 - American Cancer Society Research Scholar

2018 - National Science Foundation CAREER Award Recipient

2019 - Human Frontiers Science Program Research Grant Recipient