Sadie Wignall Associate Professor

Research Summary: 

It is estimated that 10-25% of human embryos are chromosomally abnormal, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of chromosome segregation defects in the female reproductive cells (oocytes), yet surprisingly little is known about the biological mechanisms that underlie the vulnerability of oocytes to segregation errors.  The Wignall lab is focused on investigating this important problem, by combining high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans.  Current work in the lab is focused on two major areas:  1) investigating the molecular mechanisms of spindle assembly in oocytes, and 2) exploring mechanisms of chromosome congression and segregation.

Selected Publications:

Davis-Roca, A.C., Divekar, N.S., Ng, R.K., and Wignall, S.M. (2018). “Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in C. elegans.”  PLoS Genetics, 14(9): e1007626.

Mullen, T.J. and Wignall, S.M. (2017). “Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis.” PLoS Genetics. 13(9): e1006986

Davis-Roca, A.C., Muscat, C.M., and Wignall, S.M. (2017). “Caenorhabditis elegans oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments.” Journal of Cell Biology, 216(5): 1243-1253.

Mendoza, A.D., Woodruff, T.K., Wignall, S.M., and O’Halloran, T.V. (2017). “Zinc availability during germline development impacts embryo viability in Caenorhabditis elegans.” Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. 191: 194-202.

Wolff, I.D., Tran, M.V., Mullen, T.J., Villeneuve, A.M., and Wignall, S.M. (2016). “Assembly of C. elegans acentrosomal spindles occurs without evident MTOCs and requires microtubule sorting by KLP-18/kinesin-12 and MESP-1.” Molecular Biology of the Cell. 27(20): 3122-3131.

Muscat, C.C., Torre-Santiago, K.M., Tran, M.V., Powers, J.A., and Wignall, S.M. (2015). “Kinetochore-independent chromosome segregation driven by lateral microtubule bundles.” eLife. 10.7554/eLife.06462.

Wignall SM and Villeneuve AM. (2009). “Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis.”  Nature Cell Biology. 11(7):839-844.

Selected Honors:

March of Dimes Basil O'Connor Starter Scholar Award

Damon Runyon Cancer Research Foundation Runyon-Rachleff Innovation Award

V Foundation for Cancer Research "V Scholar" Award

Chicago Biomedical Consortium Junior Investigator Recruitment Award

Damon Runyon Cancer Research Foundation Postdoctoral Fellowship