Thomas Meade Professor

Research Summary: 

Our research focuses on inorganic coordination chemistry applied in three areas: biological molecular imaging of in vivo gene expression and intracellular messengers; transition metal complexes as antiviral and antitumor drugs; and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research efforts. We are developing spectroscopic and magnetic resonance probes that incorporate novel functionality for magnetic resonance and fluorescence in vivo microscopic imaging of biological systems. Further, we are investigating the fundamental properties of long-range electron transfer events in biomolecules for the development of electronic biosensors of DNA and proteins.

Selected Publications: 

Development of Ln(III) Derivatives as 19F Parashift Probes

Kaster, M. A., Caldwell, M. A., Meade, T. J..

Inorganic Chemistry 2024, 63, 21, 9877–9887.

Musculoskeletal imaging of senescence

Daldrup-Link, H.E., Suryadevara, V., Tanyildizi, Y.,  Nernekli, K., Tang, J. -H., Meade, T. J..

Skeletal Radiology 2024

Molecular Engineering of Self-Immolative Bioresponsive MR Probes

Tang, J.-H.; Li, H.; Yuan, C.; Parigi, G.; Luchinat, C.; Meade, T. J..

Journal of the American Chemical Society 2023, 145, 10045-10050.

Engineered Non-Viral Protein Cages Modified for MR Imaging

Kaster, M.; Levasseur, M.; Edwardson, T.; Caldwell, M.; Hofmann, D.; Licciardi, G.; Parigi, G.; Luchinat, C.; Hilvert, D.; Meade, TJ.

ACS Applied Bio Materials, 2023, 6, 2, 591–602.

 

Molecular Bio-Sensors and the Role of Metal Ions

Edited by Meade, TJ.

ISBN 9781032135786

Published September 27, 2022 by CRC Press.

 

Chapter 9: Non-invasive Detection of Stem Cell Therapies Facilitated by Metal Ion-Based Contrast Agents

Dukes, M.; Modo, M.; Meade, TJ.

CRC Press, 2022; pp 261-286.

Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models

Dukes, M.; Meade, TJ.

Biomedicines, 2022, 10, 2376.

 

Functional Disruption of Gli1-DNA Recognition via a Cobalt(III) Complex

Brue, C.; Dukes, M.; Masotti, M.; Holmgren, R.; Meade, TJ.

ChemMedChem, 2022, 17, e2022000.

 

Delivery of Targeted Co(III)-DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling

Dukes, M.; Bajema, E.; Whittemore, T.; Holmgren, R.; Meade, TJ.

Bioconjugate Chem., 2022, 33, 643–653. 

Selected Honors: