Erwin Goldberg

Research Summary:

Our research focuses on the molecular and cellular biology of mammalian sperm.  At present, there is no reliable, non-hormonal and acceptable contraceptive technology available for use by men, with the exception of the condom or vasectomy. Because sperm lacking lactate dehydrogenase C (LDH-C₄) are non-functional, our research provides the basis for developing birth control methods for men with LDH-C₄, as a druggable target. We have generated a mutant mouse model of male infertility, the Ldhc null, which provides a unique biological resource for designing chemistry that will disrupt sperm function. Based on the three dimensional structure of LDHC we are able to model binding of small molecule inhibitors of this enzyme.

Selected Publications:

Tung, K. S. K., Harakal, J., Qiao, H., Rival, C., Li, J. C. H., Paul, A. G. A., Wheeler, K., Pramoonjago, P., Grafer, C. M., Sun, W., Sampson, R. D., Wong, E. W. P., Reddi, P. P., Deshmukh, U. S., Hardy, D. M., Tang, H., Cheng, C. Y. & Goldberg, E. (2017) Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance. Journal of Clinical Investigation. 127, 3, p. 1046-1060

Alves, M.G., Jesus, T.T., Sousa, M., Goldberg, E., Silva, B.M., and Oliveira, P.F. (2016) Male fertility and obesity: are ghrelin, leptin and glucagon-like peptide-1   pharmacologically relevant?  Curr Pharm. Des. 22(7):783-91.

Teng, X., Emmett, M., Lazar, M., Goldberg, E. and Rabinowitz, J.D (2016) Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chemical Biology. 11 (9), p. 2420-2427 8 p.

Payne, C. & Goldberg, E., Male contraception: Past, present and future (2014) In: Current Molecular Pharmacology. 7 (2) p. 175-181

Tang, H., Duan C., Bieher, R. and Goldberg, E. (2013) Human Lactate Dehydrogenase A (Ldha) rescues mouse Ldhc null sperm function.  Biol. Reprod. 88(4):96. PMID: 23467744          

Murdoch,  F.E. and Goldberg, E. (2013) Male contraception: Another holy grail. Bioorg.  Med. Chem. Lett.  Dec 7. pii: S0960-894X(13)01376-0. doi: 10.1016/j.bmcl. 2013.12.004.   [Epub ahead of print] PubMed PMID: 24368213.

Griswold, M.D., Eddy, M. and Goldberg, E. (2013) IN MEMORIAM: Norman B. Hecht, December 14, 1940 - February 28, 2013. Biol Reprod. May 15. [Epub ahead of print] PubMed PMID: 23677980.

Odet, F., Gabel, S., London, R.E., Goldberg, E. and Eddy, E.M. (2013) Glycolysis and mitochondrial respiration in mouse LDHC-null sperm. Biol Reprod. 88(4):95. PubMed MID: 23486916.

 

Selected Honors:

Fellow of the American Association for the Advancement of Science

State University of New York- The Degree of Doctor of Science

American Society of Andrology-Distinguished Service Award

American Society of Andrology-Distinguished Andrologist Award

President, American Society of Andrology