Carole LaBonne Professor

Research Summary:

The LaBonne lab uses biochemical and computational approaches to understand the genetic and epigenetic control of the stem cell state, and the relationship of “stemness” to the capacity for invasive cell behavior. We use in vivo approaches in developing vertebrate embryos, and ex vivo analyses, to elucidate the contributions of retained cellular potential to the evolution of vertebrate animal such as humans.

Selected Publications:

X-ray phase-contrast in vivo microtomography probes new aspects of Xenopus gastrulation. Moosmann J, Ershov A, Altapova V, Baumbach T, Prasad MS, LaBonne C, Xiao X, Kashef J, and Hofmann R. Nature. 2013 May 16;497(7499):374-377.

Interactions between Twist and other core epithelial–mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Lander R, Nasr T, Ochoa SD, Nordin K, Prasad MS, and LaBonne C. Nature Communications. 2013 February 26;4:1542.

SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest. Lee P-C, Taylor-Jaffe KM, Nordin KM, Prasad MS, Lander RM, and LaBonne C. Journal of Cell Biology. 2012 September 3;198(5):799-813.

Induction of the neural crest state: Control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions. Prasad MS, Sauka-Spengler T, and LaBonne C. Developmental Biology. 2012 June 1;366(1):10-21.

Targeted Inactivation of Snail Family EMT Regulatory Factors by a Co(III)-Ebox Conjugate. Harney AS, Meade TJ, and LaBonne C. PLoS ONE. 2012 February 29;7(2):e32318.