Ishwar Radhakrishnan Professor

Research Summary:

Our studies focus on the Sin3L/S HDAC and KAT2B HAT complexes and we are using a biochemical, computational, and structural approaches including crystallography and cryoEM approaches.

Another major project in the lab focuses on the structure, function, dynamics (aka internal motion), and evolution of nuclear receptors vis-a-vis the acquisition of ligand-binding functions.  We are asking these questions in the context of the NR5A sub-family of receptors using a combination of phylogenetic analyses, site-directed mutagenesis complemented by functional assays, solution NMR spectroscopy, x-ray crystallography, and molecular dynamics simulations.
Selected Publications:

Selected Publications:

Clark, M.D., Kumar, G.S., Marcum, R., Luo, Q., Zhang, Y., and Radhakrishnan, I. (2015). Molecular basis for the mechanism of constitutive CBP/p300 coactivator recruitment by CRTC1-MAML2 and its implications in cAMP signaling. Biochemistry 54, 5439-5446.

Clark, M.D., Marcum, R., Graveline, R., Chan, C.W., Xie, R. Chen, Z., Ding, Y., Zhang, Y., Mondragón, A., David, G., and Radhakrishnan, I. (2015). Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proc. Natl. Acad. Sci. USA 112, E3669-E3678.

Xie, T., Zmyslowski, M., Zhang, Y., and Radhakrishnan, I. (2015). Multi-specificity of MRG domains. Structure 23, 1049-1057.


Selected Honors:

Jane Coffin Childs Memorial Fund for Medical Research Fellow, 1995-1998

Basil O’Connor Starter Scholar of the March of Dimes Birth Defects Foundation, 2001-2002

Scholar of the Leukemia and Lymphoma Society, 2004-2009