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Submenu for: PeopleThomas O'Halloran Professor
Research Summary:
The O’Halloran research group adopts a highly interdisciplinary approach using biochemistry, molecular biology and imaging techniques to quantitatively understand the molecular mechanisms and regulatory roles of the cellular metallome.
Selected Publications:
Mendoza AD, Woodruff TK, Wignall, O’Halloran TV. “Zinc Availability During Germline Development Impacts Embryo Viability in Caenorhabditis elegans” Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology (2016) accepted for publication.
Ugolkov, A, Gaisina I, Zhang, J-S, Billadeau,D, White, K, Kozikowski, A, Jain, S, Cristofanilli, M, Giles, F, O’Halloran, T, Cryns, V, Mazar, A. “GSK-3 inhibition overcomes chemoresistance in human breast cancer” Cancer Letters (2016) Oct 1;380(2):384-92. doi: 10.1016/j.canlet.2016.07.006. Epub 2016 Jul 14. PMID: 27424289.
Upreti M, Jyoti A, Johnson SE, Swindell EP, Napier D, Sethi P, Chan R, Feddock JM, Weiss HL, O’Halloran TV, Evers BM. “Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer.” Oncotarget 2016 May 19. doi: 10.18632/oncotarget.9490. [Epub ahead of print] PMID: 27223428
Duncan FE, Que EL, Zhang N, Feinberg EC, O’Halloran TV, Woodruff TK. “The zinc spark is an inorganic signature of human egg activation” Scientific Reports. 2016 Apr 26;6:24737. doi: 10.1038/srep24737
Mazar AP, Ugolkov A, Henkin J, Ahn RW and O’Halloran TV, “Chapter 7: Invasion and metastasis” in Oxford Textbook of Oncology, 3rd Edition, edited by David J. Kerr, Daniel G. Haller, Cornelis J.H. van de Velde, Michael Baumann, Nagahiro Saijo, Oxford, UK:Oxford University Press, pp. 61-71, 2016
Zhang N, Duncan FE, Que EL, O’Halloran TV, Woodruff TK. “The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development” Scientific Reports. 2016 March 18;6:22772. doi: 10.1038/srep22772