Xiaozhong Wang Associate Professor

Research Summary: 

The Wang lab uses genomics approaches to investigate regulatory pathways in mammalian stem cells. Frist, we are interested in how nucleosome organization influences gene expression. Second, we are investigating how RNA ligases regulate cellular stress responses.

Selected Publications:

Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing. Su H, Meng S, Lu Y, Trombly MI, Chen J, Lin C, Turk A, and Wang X. Molecular Cell. 2011 July 8;43(1):97-109.

PDCD10/CCM3 Acts Downstream of γ-Protocadherins to Regulate Neuronal Survival. Lin C, Meng S, Zhu T, and Wang X. Journal of Biological Chemistry. 2010 December 31;285(53):41675-41685.

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, and Bass J. Nature. 2010 July 29;466(7306):627-631.

Proteomics Analysis Reveals Overlapping Functions of Clustered Protocadherins. Han M-H, Lin C, Meng S, and Wang X. Molecular & Cellular Proteomics. 2010 January 1;9(1):71-83.

Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Su H, Trombly MI, Chen J, and Wang X. Genes & Development. 2009 February 1;23(3):304-317.